产品名称
GTF2B Rabbit Polyclonal Antibody (N-term)
别名
Transcription initiation factor IIB, General transcription factor TFIIB, S300-II, GTF2B, TF2B, TFIIB
Human Gene ID
NP_001505.1
Human Swissprot No.
Q00403
特异性
This GTF2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human GTF2B.
背景介绍
This gene encodes the general transcription factor IIB,
one of the ubiquitous factors required for transcription initiation
by RNA polymerase II. The protein localizes to the nucleus where it
forms a complex (the DAB complex) with transcription factors IID
and IIA. Transcription factor IIB serves as a bridge between IID,
the factor which initially recognizes the promoter sequence, and
RNA polymerase II.
组织表达
Expressed in the inner cell mass forming the embryoblast (PubMed:24441171). Not detected in cells from the outer thin layer trophoblast (at protein level) (PubMed:24441171)
细胞定位
Nucleus. Chromosome. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
