产品名称
WNT7A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00755
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00755/entry
Mouse Swissprot No.
P24383
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P24383
免疫原
Synthesized peptide derived from human protein . at AA range: 110-190
特异性
WNT7A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008],
组织表达
Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
细胞定位
Secreted, extracellular space, extracellular matrix . Secreted .
信号通路
WNT;WNT-T CELLHedgehog;Melanogenesis;Pathways in cancer;Basal cell carcinoma;
功能
disease:Defects in WNT7A are a cause of Fuhrmann syndrome [MIM:228930]; also called fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.,disease:Defects in WNT7A are the cause of limb/pelvis-hypoplasia/aplasia syndrome (LPHAS) [MIM:276820]; also called absence of ulna and fibula with severe limb deficiency. LPHAS is a limb-malformation disorder characterized by various degrees of limb aplasia/hypoplasia and joint dysplasia.,function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN.,tissue specificity:Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
