BD-PB1272-Mouse Dyrk2 Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

Mouse Dyrk2 Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB1272

产品名称

Mouse Dyrk2 Rabbit Polyclonal Antibody (C-term)

别名

Dual specificity tyrosine-phosphorylation-regulated kinase 2, Dyrk2 {ECO:0000312|MGI:MGI:1330301}

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Swissprot No.

Q5U4C9

Mouse Gene ID

NP_001014412.1

特异性

This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of mouse Dyrk2.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

67kDa

同种型

Rabbit Ig

背景介绍

Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).

细胞定位

Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q92630}. Note=Translocates into the nucleus following DNA damage. {ECO:0000250|UniProtKB:Q92630}

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Anti-Dyrk2 Antibody (C-term) at 1:8000 dilution + C2C12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Mouse Dyrk2 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Dyrk2 antibody detected the Dyrk2 protein (arrow).

Mouse Dyrk2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Dyrk2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.