产品名称
VPRBP Rabbit Polyclonal Antibody
基因名称
VPRBP DCAF1 KIAA0800 RIP
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9730
Human Swissprot No.
Q9Y4B6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y4B6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/321006
Mouse Swissprot No.
Q80TR8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TR8
免疫原
Synthesized peptide derived from human VPRBP AA range: 804-854
特异性
This antibody detects endogenous levels of VPRBP at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm. Nucleus. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis.
功能
domain:Although not canonical, the WD repeat-like region is related to WD repeats.,function:May act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 and arrest the cell cycle in G2 phase.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the VPRBP family.,similarity:Contains 1 LisH domain.,subunit:Interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex. In case of infection, interacts with HIV-1 virus Vpr protein and forms a ternary complex with HIV-1 Vpr and DDB1.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
