产品名称
CELA2A Rabbit Polyclonal Antibody (C-term)
别名
Chymotrypsin-like elastase family member 2A, Elastase-2A, CELA2A, ELA2A
Human Gene ID
NP_254275.1
Human Swissprot No.
P08217
特异性
This CELA2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human CELA2A.
背景介绍
Elastases form a subfamily of serine proteases that
hydrolyze many proteins in addition to elastin. Humans have six
elastase genes which encode the structurally similar proteins
elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human
elastases, elastase 2A is secreted from the pancreas as a zymogen.
In other species, elastase 2A has been shown to preferentially
cleave proteins after leucine, methionine, and phenylalanine
residues.
组织表达
Expressed in pancreas. Not detected in keratinocytes (PubMed:10620133). Detected in exocrine secretions of the pancreas (at protein level). Also expressed in a small fraction of cells in pancreatic islets, adrenal cortex, intestinal glands and colonic lymphoid follicles (at protein level) (PubMed:31358993) Detected in plasma (PubMed:31358993).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
