产品名称
HIST2H2AA4 Rabbit Polyclonal Antibody (C-term)
别名
Histone H2A type 2-A, Histone H2A2, Histone H2A/o, HIST2H2AA3, H2AFO, HIST2H2AA
Human Gene ID
NP_001035807.1;NP_003507.1
Human Swissprot No.
Q6FI13
特异性
This HIST2H2AA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human HIST2H2AA4.
背景介绍
Histones are basic nuclear proteins that are responsible
for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A,
H2B, H3, and H4) form an octamer, around which approximately 146 bp
of DNA is wrapped in repeating units, called nucleosomes. The
linker histone, H1, interacts with linker DNA between nucleosomes
and functions in the compaction of chromatin into higher order
structures. This gene is intronless and encodes a member of the
histone H2A family. Transcripts from this gene lack polyA tails but
instead contain a palindromic termination element. This gene is
found in a histone cluster on chromosome 1. This gene is one of
four histone genes in the cluster that are duplicated; this record
represents the telomeric copy.
细胞定位
Nucleus. Chromosome.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
