产品名称
Mouse Ntrk2 Rabbit Polyclonal Antibody (Center)
别名
BDNF/NT-3 growth factors receptor, GP145-TrkB/GP95-TrkB, Trk-B, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Ntrk2, Trkb
Human Swissprot No.
P15209
Mouse Gene ID
NP_001020245.1;NP_032771.1
特异性
This Mouse Ntrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the Central region of mouse Ntrk2.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
组织表达
Expressed in the brain, in neurons (at protein level) (PubMed:23977241). Detected in hippocampus (at protein level) (PubMed:27457814). Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform GP95-TRKB is specifically expressed in glial cells.
细胞定位
Cell membrane; Single-pass type I membrane protein Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon {ECO:0000250|UniProtKB:Q63604}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63604}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63604}. Cell junction, synapse, postsynaptic density. Note=Internalized to endosomes upon ligand-binding.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.