产品名称
PPP1CB Rabbit Polyclonal Antibody (C-term)
别名
Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B, PPP1CD, PPP1CB
Human Gene ID
NP_002700.1;NP_996759.1
Human Swissprot No.
P62140
特异性
This PPP1CB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the C-terminal region of human PPP1CB.
背景介绍
The protein encoded by this gene is one of the three
catalytic subunits of protein phosphatase 1 (PP1). PP1 is a
serine/threonine specific protein phosphatase known to be involved
in the regulation of a variety of cellular processes, such as cell
division, glycogen metabolism, muscle contractility, protein
synthesis, and HIV-1 viral transcription. Mouse studies suggest
that PP1 functions as a suppressor of learning and memory. Two
alternatively spliced transcript variants encoding distinct
isoforms have been observed.
细胞定位
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
