产品名称
POF1B Rabbit Polyclonal Antibody (Center)
别名
Protein POF1B, Premature ovarian failure protein 1B, POF1B
Human Gene ID
NP_079197.3
Human Swissprot No.
Q8WVV4
特异性
This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.
背景介绍
Premature ovarian failure (POF) is characterized by
primary or secondary amenorrhea in women less than 40 years old.
Two POF susceptibility regions called 'POF1' and 'POF2' have been
identified by breakpoint mapping of X-autosome translocations. POF1
extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1.
This gene, POF1B, resides in the POF2 region. This gene is
expressed at trace levels in mouse prenatal ovary and is barely
detectable or absent from adult ovary, in human and in the mouse
respectively. This gene's expression is restricted to epithelia
with its highest expression in the epidermis, and oro-pharyngeal
and gastro-intestinal tracts. The protein encoded by this gene
binds non-muscle actin filaments. The role this gene may play in
the etiology of premature ovarian failure remains to be determined.
细胞定位
Cell junction, tight junction
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
