产品名称
EHD1 Rabbit Polyclonal Antibody (C-term)
别名
EH domain-containing protein 1, PAST homolog 1, hPAST1, Testilin, EHD1, PAST, PAST1
Human Gene ID
NP_001269373.1;NP_001269374.1;NP_006786.2
Human Swissprot No.
Q9H4M9
特异性
This EHD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-438 amino acids from the C-terminal region of human EHD1.
背景介绍
This gene belongs to a highly conserved gene family
encoding EPS15 homology (EH) domain-containing proteins. The
protein-binding EH domain was first noted in EPS15, a substrate for
the epidermal growth factor receptor. The EH domain has been shown
to be an important motif in proteins involved in protein-protein
interactions and in intracellular sorting. The protein encoded by
this gene is thought to play a role in the endocytosis of IGF1
receptors.
组织表达
Highly expressed in testis.
细胞定位
Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000250|UniProtKB:Q9WVK4}; Peripheral membrane protein; Cytoplasmic side. Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity) Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity) {ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:25686250}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.