产品名称
MARCH11 Rabbit Polyclonal Antibody (C-term)
别名
E3 ubiquitin-protein ligase MARCH11, 632-, Membrane-associated RING finger protein 11, Membrane-associated RING-CH protein XI, MARCH-XI, MARCH11
Human Gene ID
NP_001096032.1
Human Swissprot No.
A6NNE9
特异性
This MARCH11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human MARCH11.
背景介绍
MARCH11 is a member of the MARCH family of membrane-bound
E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin
(see MIM 191339) to target lysines in substrate proteins, thereby
signaling their intracellular transport. March11 appears to have a
role in ubiquitin-mediated protein sorting in the trans-Golgi
network (TGN)-multivesicular body (MVB) transport pathway (Morokuma
et al., 2007 [PubMed 17604280]).
细胞定位
Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:A6P320}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A6P320}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
