产品名称
FOLH1 Rabbit Polyclonal Antibody (N-term)
别名
Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
Human Gene ID
NP_001014986.1;NP_001180400.1;NP_001180401.1;NP_001180402.1;NP_004467.1
Human Swissprot No.
Q04609
特异性
This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.
稀释度
WB~~1:1000;IHC-P~~1:100~500;IF~~1:10~50
背景介绍
This gene encodes a type II transmembrane glycoprotein
belonging to the M28 peptidase family. The protein acts as a
glutamate carboxypeptidase on different alternative substrates,
including the nutrient folate and the neuropeptide
N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of
tissues such as prostate, central and peripheral nervous system and
kidney. A mutation in this gene may be associated with impaired
intestinal absorption of dietary folates, resulting in low blood
folate levels and consequent hyperhomocysteinemia. Expression of
this protein in the brain may be involved in a number of
pathological conditions associated with glutamate excitotoxicity.
In the prostate the protein is up-regulated in cancerous cells and
is used as an effective diagnostic and prognostic indicator of
prostate cancer. This gene likely arose from a duplication event of
a nearby chromosomal region. Alternative splicing gives rise to
multiple transcript variants encoding several different isoforms.
组织表达
Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver Isoform PSMA-9 is specifically expressed in prostate cancer
细胞定位
Cell membrane; Single-pass type II membrane protein
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
