产品名称
HLA-DRB4 Rabbit Polyclonal Antibody (N-term)
别名
HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4, HLA-DRB4
Human Gene ID
NP_068818.4
Human Swissprot No.
P13762
特异性
This HLA-DRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human HLA-DRB4.
背景介绍
HLA-DRB4 belongs to the HLA class II beta chain
paralogues. This class II molecule is a heterodimer consisting of
an alpha (DRA) and a beta (DRB) chain, both anchored in the
membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II
molecules are expressed in antigen presenting cells (APC: B
lymphocytes, dendritic cells, macrophages). The beta chain is
approximately 26-28 kDa and its gene contains 6 exons. Exon one
encodes the leader peptide, exons 2 and 3 encode the two
extracellular domains, exon 4 encodes the transmembrane domain and
exon 5 encodes the cytoplasmic tail. Within the DR molecule the
beta chain contains all the polymorphisms specifying the peptide
binding specificities. Typing for these polymorphisms is routinely
done for bone marrow and kidney transplantation. DRB1 is expressed
at a level five times higher than its paralogues DRB3, DRB4 and
DRB5. The presence of DRB4 is linked with allelic variants of DRB1,
otherwise it is omitted. There are 4 related pseudogenes: DRB2,
DRB6, DRB7, DRB8 and DRB9.
细胞定位
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.