产品名称
SERPH Rabbit Polyclonal Antibody
基因名称
SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14
蛋白名称
Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P50454
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P50454/entry
Mouse Swissprot No.
P19324
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P19324
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P29457
免疫原
Synthesized peptide derived from human protein . at AA range: 190-270
特异性
SERPH Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011],
组织表达
Brain,Cartilage,Fibroblast,Ovary,Periodontal ligament,Skin,
细胞定位
Endoplasmic reticulum lumen.
功能
function:Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.,induction:By heat shock.,polymorphism:A functional SNP in the promoter of SERPINH1 is associated in African Americans with an increased risk for preterm premature rupture of membranes (PPROM) [MIM:610504]. PPROM is defined as rupture of the membranes before 37 weeks of gestation. SERPINH1 with the -656 T allele displays significantly reduced promoter activity compared to the major -656 C allele. Prematurity is correlated with an increased frequency of the -656 T allele.,similarity:Belongs to the serpin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
