产品名称
NLRP6 Rabbit Polyclonal Antibody (N-term)
别名
NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Human Gene ID
NP_001263629.1;NP_612202.2
Human Swissprot No.
P59044
特异性
This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6.
背景介绍
NALPs are cytoplasmic proteins that form a subfamily
within the larger CATERPILLER protein family. Most short NALPs,
such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain
(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),
and a C-terminal leucine-rich repeat (LRR) region. The long NALP,
NALP1 (MIM 606636), also has a C-terminal extension containing a
function to find domain (FIIND) and a caspase recruitment domain
(CARD). NALPs are implicated in the activation of proinflammatory
caspases (e.g., CASP1; MIM 147678) via their involvement in
multiprotein complexes called inflammasomes (Tschopp et al., 2003
[PubMed 12563287]).
组织表达
Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405).
细胞定位
Cytoplasm. Inflammasome. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Nucleus membrane {ECO:0000250|UniProtKB:Q63035}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
