产品名称
PTPLA Rabbit Polyclonal Antibody (N-term)
别名
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1, 3-hydroxyacyl-CoA dehydratase 1, HACD1, Cementum attachment protein, Protein-tyrosine phosphatase-like member A, PTPLA, HACD1
Human Gene ID
NP_055056.3
Human Swissprot No.
B0YJ81
特异性
This PTPLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human PTPLA.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
The protein encoded by this gene contains a characteristic
catalytic motif of the protein tyrosine phosphatases (PTPs) family.
The PTP motif of this protein has the highly conserved arginine
residue replaced by a proline residue; thus it may represent a
distinct class of PTPs. Members of the PTP family are known to be
signaling molecules that regulate a variety of cellular processes.
This gene was preferentially expressed in both adult and fetal
heart. A much lower expression level was detected in skeletal and
smooth muscle tissues, and no expression was observed in other
tissues. The tissue specific expression in the developing and adult
heart suggests a role in regulating cardiac development and
differentiation.
组织表达
Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203).
细胞定位
[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
