产品名称
SSX4 Rabbit Polyclonal Antibody (Center)
别名
Protein SSX4, Cancer/testis antigen 54, CT54, SSX4, SSX4A
Human Gene ID
NP_001030004.1;NP_001035702.1;NP_005627.1;NP_783856.1
Human Swissprot No.
O60224
特异性
This SSX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human SSX4.
背景介绍
The product of this gene belongs to the family of highly
homologous synovial sarcoma X (SSX) breakpoint proteins. These
proteins may function as transcriptional repressors. They are also
capable of eliciting spontaneously humoral and cellular immune
responses in cancer patients, and are potentially useful targets in
cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have
been involved in the t(X;18) translocation characteristically found
in all synovial sarcomas. This translocation results in the fusion
of the synovial sarcoma translocation gene on chromosome 18 to one
of the SSX genes on chromosome X. Chromosome Xp11 contains a
segmental duplication resulting in two identical copies of synovial
sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail
orientation. This gene, SSX4B, represents the more centromeric
copy. Two transcript variants encoding distinct isoforms have been
identified for this gene.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
