产品名称
PAPOLG Rabbit Polyclonal Antibody (C-term)
别名
Poly(A) polymerase gamma, PAP-gamma, Neo-poly(A) polymerase, Neo-PAP, Polynucleotide adenylyltransferase gamma, SRP RNA 3'-adenylating enzyme, PAPOLG, PAP2, PAPG
Human Gene ID
NP_075045.2
Human Swissprot No.
Q9BWT3
特异性
This PAPOLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685-714 amino acids from the C-terminal region of human PAPOLG.
背景介绍
This gene encodes a member of the poly(A) polymerase
family which catalyzes template-independent extension of the 3' end
of a DNA/RNA strand. This enzyme shares 60% identity to the well
characterized poly(A) polymerase II (PAPII) at the amino acid
level. These two enzymes have similar organization of structural
and functional domains. This enzyme is exclusively localized in the
nucleus and exhibits both nonspecific and CPSF (cleavage and
polyadenylation specificity factor)/AAUAAA-dependent
polyadenylation activity. This gene is located on chromosome 2 in
contrast to the PAPII gene, which is located on chromosome 14.
组织表达
Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
