产品名称
NFAM1 Rabbit Polyclonal Antibody
蛋白名称
NFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NET5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NET5/entry
Mouse Swissprot No.
Q8R4V1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4V1
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
NFAM1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Partially recruited to lipid rafts upon BCR stimulation. .
功能
domain:The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.,function:May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.,PTM:N-glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Partially recruited to lipid rafts upon BCR stimulation.,subunit:Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR).,tissue specificity:Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
