产品名称
LZTS1 Rabbit Polyclonal Antibody (N-term)
别名
Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1
Human Gene ID
NP_066300.1
Human Swissprot No.
Q9Y250
特异性
This LZTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human LZTS1.
背景介绍
This gene encodes a tumor suppressor protein that is
ubiquitously expressed in normal tissues. In uveal melanomas,
expression of this protein is silenced in rapidly metastasizing and
metastatic tumor cells but has normal expression in slowly
metastasizing or nonmetastasizing tumor cells. This protein may
have a role in cell-cycle control by interacting with the
Cdk1/cyclinB1 complex. This gene is located on chromosomal region
8p22. Loss of heterozygosity (LOH) in the 8p arm is a common
characteristic of many types of cancer.
组织表达
Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas Not detectable in primary tumors from breast and prostate and in many cancer cell lines.
细胞定位
Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
