产品名称
PLEKHM1 Rabbit Polyclonal Antibody (N-term)
别名
Pleckstrin homology domain-containing family M member 1, PH domain-containing family M member 1, 162 kDa adapter protein, AP162, PLEKHM1, KIAA0356
Human Gene ID
NP_055613.1
Human Swissprot No.
Q9Y4G2
特异性
This PLEKHM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human PLEKHM1.
背景介绍
The protein encoded by this gene is essential for bone
resorption, and may play a critical role in vesicular transport in
the osteoclast. Mutations in this gene are associated with
autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively
spliced transcript variants have been found for this gene.
组织表达
Expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine Predominantly expressed in the breast carcinoma cell line MCF-7
细胞定位
Autolysosome membrane. Endosome membrane. Late endosome membrane. Lysosome membrane. Note=In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV) (PubMed:25500191).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
