产品名称
NB5R4 Rabbit Polyclonal Antibody
蛋白名称
Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7L1T6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7L1T6/entry
Mouse Swissprot No.
Q3TDX8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TDX8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q68EJ0
免疫原
Synthesized peptide derived from human protein . at AA range: 380-460
特异性
NB5R4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010],
细胞定位
Endoplasmic reticulum . Soluble protein.
功能
catalytic activity:NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.,cofactor:FAD.,function:NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.,polymorphism:Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.,similarity:Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.,similarity:Contains 1 CS domain.,similarity:Contains 1 cytochrome b5 heme-binding domain.,similarity:Contains 1 FAD-binding FR-type domain.,subcellular location:Soluble protein.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
