产品名称
LZTS2 Rabbit Polyclonal Antibody (C-term)
别名
Leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026}, hLZTS2, Protein LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026}, LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026}
Human Gene ID
NP_115805.1
Human Swissprot No.
Q9BRK4
特异性
This LZTS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-601 amino acids from the C-terminal region of human LZTS2.
背景介绍
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
组织表达
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
