产品名称
MYLK2 Rabbit Polyclonal Antibody
蛋白名称
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H1R3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H1R3/entry
Mouse Swissprot No.
Q8VCR8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCR8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P20689
免疫原
Synthesized peptide derived from human protein . at AA range: 370-450
特异性
MYLK2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008],
组织表达
Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
细胞定位
Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
信号通路
Calcium;Vascular smooth muscle contraction;Focal adhesion;Regulates Actin and Cytoskeleton;
功能
catalytic activity:ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.,disease:Defects in MYLK2 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,function:Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.,tissue specificity:Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
