产品名称
PLOD3 Rabbit Polyclonal Antibody (N-term)
别名
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3, Lysyl hydroxylase 3, LH3, PLOD3
Human Gene ID
NP_001075.1
Human Swissprot No.
O60568
特异性
This PLOD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-105 amino acids from the N-terminal region of human PLOD3.
背景介绍
The protein encoded by this gene is a membrane-bound
homodimeric enzyme that is localized to the cisternae of the rough
endoplasmic reticulum. The enzyme (cofactors iron and ascorbate)
catalyzes the hydroxylation of lysyl residues in collagen-like
peptides. The resultant hydroxylysyl groups are attachment sites
for carbohydrates in collagen and thus are critical for the
stability of intermolecular crosslinks. Some patients with
Ehlers-Danlos syndrome type VIB have deficiencies in lysyl
hydroxylase activity.
组织表达
Ubiquitous (PubMed:9724729). Detected in heart, placenta and pancreas and at lower levels in lung, liver and skeletal muscle (PubMed:9582318, PubMed:9724729).
细胞定位
Rough endoplasmic reticulum. Endoplasmic reticulum lumen. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9R0E1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0E1}; Lumenal side {ECO:0000250|UniProtKB:Q9R0E1}. Secreted Secreted, extracellular space {ECO:0000250|UniProtKB:Q9R0E1}. Note=The majority of the secreted protein is associated with the extracellular matrix. {ECO:0000250|UniProtKB:Q9R0E1}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
