产品名称
MX1 Rabbit Polyclonal Antibody
蛋白名称
Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P20591
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20591/entry
Mouse Swissprot No.
P09922
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09922
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P18588
免疫原
Synthesized peptide derived from human protein . at AA range: 500-580
特异性
MX1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
Primary B-Cells,Spleen,Uterus,
细胞定位
Cytoplasm . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, perinuclear region . Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845). .; [Isoform 2]: Cytoplasm . Nucleus . Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636). .
功能
function:May regulate the calcium channel activity of TRPCs. Shows activity against influenza virus and VSV, a rhabdovirus.,induction:By interferons.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,subunit:Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
