产品名称
BPGM Rabbit Polyclonal Antibody (C-term)
别名
Bisphosphoglycerate mutase, BPGM,3-bisphosphoglycerate mutase, erythrocyte,3-bisphosphoglycerate synthase,3-diphosphoglycerate mutase, DPGM, BPG-dependent PGAM, BPGM
Human Gene ID
NP_001715.1;NP_954655.1
Human Swissprot No.
P07738
特异性
This BPGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-259 amino acids from the C-terminal region of human BPGM.
背景介绍
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found
at high concentrations in red blood cells where it binds to and
decreases the oxygen affinity of hemoglobin. This gene encodes a
multifunctional enzyme that catalyzes 2,3-DPG synthesis via its
synthetase activity, and 2,3-DPG degradation via its phosphatase
activity. The enzyme also has phosphoglycerate phosphomutase
activity. Deficiency of this enzyme increases the affinity of cells
for oxygen. Mutations in this gene result in hemolytic anemia.
Multiple alternatively spliced variants, encoding the same protein,
have been identified.
组织表达
Expressed in red blood cells. Expressed in non- erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface (at protein level).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
