产品名称
SCAP Rabbit Polyclonal Antibody (N-term)
别名
Sterol regulatory element-binding protein cleavage-activating protein, SCAP, SREBP cleavage-activating protein, SCAP, KIAA0199
Human Gene ID
NP_036367.2
Human Swissprot No.
Q12770
特异性
This SCAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human SCAP.
背景介绍
This gene encodes a protein with a sterol sensing domain
(SSD) and seven WD domains. In the presence of cholesterol, this
protein binds to sterol regulatory element binding proteins
(SREBPs) and mediates their transport from the ER to the Golgi. The
SREBPs are then proteolytically cleaved and regulate sterol
biosynthesis.
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane {ECO:0000250|UniProtKB:P97260}; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity) Requires the presence of SPRING1 for proper localization to endoplasmic reticulum (PubMed:32111832). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:32111832}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
