产品名称
DAZ2 Rabbit Polyclonal Antibody (C-term)
别名
Deleted in azoospermia protein 2, DAZ2
Human Gene ID
NP_001005785.1;NP_001005786.2;NP_065096.2
Human Swissprot No.
Q13117
特异性
This DAZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-546 amino acids from the C-terminal region of human DAZ2.
背景介绍
This gene is a member of the DAZ gene family and is a
candidate for the human Y-chromosomal azoospermia factor (AZF). Its
expression is restricted to premeiotic germ cells, particularly in
spermatogonia. It encodes an RNA-binding protein that is important
for spermatogenesis. Four copies of this gene are found on
chromosome Y within palindromic duplications; one pair of genes is
part of the P2 palindrome and the second pair is part of the P1
palindrome. Each gene contains a 2.4 kb repeat including a 72-bp
exon, called the DAZ repeat; the number of DAZ repeats is variable
and there are several variations in the sequence of the DAZ repeat.
Each copy of the gene also contains a 10.8 kb region that may be
amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains one copy of the
10.8 kb repeat. Alternative splicing results in multiple transcript
variants encoding different isoforms.
细胞定位
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
