产品名称
POU6F2 Rabbit Polyclonal Antibody (N-term)
别名
POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF-1, POU6F2, RPF1
Human Gene ID
NP_001159490.1;NP_009183.3
Human Swissprot No.
P78424
特异性
This POU6F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human POU6F2.
背景介绍
This gene encodes a member of the POU protein family
characterized by the presence of a bipartite DNA binding domain,
consisting of a POU-specific domain and a homeodomain, separated by
a variable polylinker. The DNA binding domain may bind to DNA as
monomers or as homo- and/or heterodimers, in a sequence-specific
manner. The POU family members are transcriptional regulators, many
of which are known to control cell type-specific differentiation
pathways. This gene is a tumor suppressor involved in Wilms tumor
(WT) predisposition. Alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene.
组织表达
Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
