BD-PB0946-PLAG1 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

PLAG1 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB0946

产品名称

PLAG1 Rabbit Polyclonal Antibody (N-term)

别名

Zinc finger protein PLAG1, Pleiomorphic adenoma gene 1 protein, PLAG1

类别

常规抗体

推荐应用

反应种属

Human, Rat, Mouse

Human Gene ID

NP_001108106.1;NP_001108107.1;NP_002646.2

Human Swissprot No.

Q6DJT9

特异性

This PLAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of human PLAG1.

稀释度

WB~~1:1000

预测分子量

56kDa

同种型

Rabbit Ig

背景介绍

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.

组织表达

Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.

细胞定位

Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

All lanes : Anti-PLAG1 Antibody (N-term) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

PLAG1 Antibody (N-term) western blot analysis in NCI-H460,K562 cell line lysates (35ug/lane).This demonstrates the PLAG1 antibody detected the PLAG1 protein (arrow).