BD-PB0933-Rad9 Rabbit Polyclonal Antibody (S387)-现货抗体产品库武汉枢密脑科学技术有限公司

Rad9 Rabbit Polyclonal Antibody (S387)

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产品基本信息

产品货号

BD-PB0933

产品名称

Rad9 Rabbit Polyclonal Antibody (S387)

别名

Cell cycle checkpoint control protein RAD9A, hRAD9, DNA repair exonuclease rad9 homolog A, RAD9A

类别

常规抗体

推荐应用

反应种属

Human, Rat, Mouse

Human Gene ID

NP_001230153.1;NP_004575.1

Human Swissprot No.

Q99638

特异性

This Rad9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 amino acids from human Rad9.

稀释度

WB~~1:1000;IHC-P~~1:100~500;IF~~1:10~50

预测分子量

43kDa

同种型

Rabbit Ig

背景介绍

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene.

细胞定位

Nucleus.

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Rad9 Antibody (pS387) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the Rad9 antibody detected the Rad9 protein (arrow).

Rad9 Antibody (S387)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Rad9 Antibody (S387) for immunohistochemistry. Clinical relevance has not been evaluated.

Confocal immunofluorescent analysis of Rad9 Antibody (S387) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).