产品名称
KRT25 Rabbit Polyclonal Antibody (C-term)
别名
Keratin, type I cytoskeletal 25, Cytokeratin-25, CK-25, Keratin-25, K25, Keratin-25A, K25A, Type I inner root sheath-specific keratin-K25irs1, KRT25 (
HGNC:30839)
Human Gene ID
NP_853512.1
Human Swissprot No.
Q7Z3Z0
特异性
This KRT25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-408 amino acids from the C-terminal region of human KRT25.
稀释度
WB~~1:1000;FC~~1:10~50
背景介绍
This gene encodes a member of the type I (acidic) keratin
family, which belongs to the superfamily of intermediate filament
(IF) proteins. Keratins are heteropolymeric structural proteins
which form the intermediate filament. These filaments, along with
actin microfilaments and microtubules, compose the cytoskeleton of
epithelial cells. The type I keratin genes are clustered in a
region of chromosome 17q12-q21.
组织表达
Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level)
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:Q8VCW2}.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
