产品名称
K1C9 Rabbit Polyclonal Antibody
蛋白名称
Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P35527
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P35527/entry
Mouse Swissprot No.
Q6RHW0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6RHW0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8CIS9
免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
K1C9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
keratin 9(KRT9) Homo sapiens This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the terminally differentiated epidermis of palms and soles.
细胞定位
extracellular space,nucleus,intermediate filament,membrane,extracellular exosome,
功能
caution:Was originally (PubMed:2140676) thought to be a 60 kDa chain of placental scatter protein.,disease:Defects in KRT9 are a cause of palmoplantar keratoderma epidermolytic (EPPK) [MIM:144200]; also abbreviated EHPPK. EPPK is a dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins.,disease:Knuckle pads are sometimes associated with EPPK [MIM:149100]. Knuckle pads consist of an autosomal dominant trait, in which thick pads of skin appear over the proximal phalangeal joints.,function:May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.,induction:Induced by intrinsic regulatory mechanisms and by extrinsic signals from a subset of dermal palmoplantar fibroblasts.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in the terminally differentiated epidermis of palms and soles.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
