产品名称
CFH Rabbit Polyclonal Antibody (Center)
别名
Complement factor H, H factor 1, CFH, HF, HF1, HF2
Human Gene ID
NP_000177.2
Human Swissprot No.
P08603
特异性
This CFH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human CFH.
稀释度
WB~~1:2000;IF~~1:10~50;IHC-P~~1:100~500
背景介绍
This gene is a member of the Regulator of Complement
Activation (RCA) gene cluster and encodes a protein with twenty
short concensus repeat (SCR) domains. This protein is secreted into
the bloodstream and has an essential role in the regulation of
complement activation, restricting this innate defense mechanism to
microbial infections. Mutations in this gene have been associated
with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic
nephropathy. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized.
组织表达
Expressed in the retinal pigment epithelium (at protein level) (PubMed:25136834). CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells (PubMed:6444659, PubMed:2968404, PubMed:2139673, PubMed:25136834)
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
