产品名称
MAPK8 Rabbit Polyclonal Antibody (T183/Y185)
别名
Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8, JNK1, PRKM8, SAPK1, SAPK1C
Human Gene ID
NP_001265476.1;NP_002741.1;NP_620634.1;NP_620637.1
Human Swissprot No.
P45983
特异性
This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-195 amino acids from human MAPK8.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases act as an integration point for multiple
biochemical signals, and are involved in a wide variety of cellular
processes such as proliferation, differentiation, transcription
regulation and development. This kinase is activated by various
cell stimuli, and targets specific transcription factors, and thus
mediates immediate-early gene expression in response to cell
stimuli. The activation of this kinase by tumor-necrosis factor
alpha (TNF-alpha) is found to be required for TNF-alpha induced
apoptosis. This kinase is also involved in UV radiation induced
apoptosis, which is thought to be related to cytochrom c-mediated
cell death pathway. Studies of the mouse counterpart of this gene
suggested that this kinase play a key role in T cell proliferation,
apoptosis and differentiation. Four alternatively spliced
transcript variants encoding distinct isoforms have been reported.
细胞定位
Cytoplasm. Nucleus. Cell junction, synapse {ECO:0000250|UniProtKB:P49185}. Note=In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
