产品名称
K1C12 Rabbit Polyclonal Antibody
蛋白名称
Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99456
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99456/entry
Mouse Swissprot No.
Q64291
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64291
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6IFW5
免疫原
Synthesized peptide derived from human protein . at AA range: 200-280
特异性
K1C12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the corneal epithelium (at protein level).
细胞定位
intermediate filament,extracellular exosome,
功能
disease:Defects in KRT12 are a cause of juvenile epithelial corneal dystrophy of Meesmann (MCD) [MIM:122100]. MCD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.,function:May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,online information:Keratin-12 entry,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.,tissue specificity:Cornea specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
