产品名称
KDM5A Rabbit Polyclonal Antibody
基因名称
KDM5A JARID1A RBBP2 RBP2
蛋白名称
Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P29375
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P29375/entry
Mouse Swissprot No.
Q3UXZ9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UXZ9
免疫原
Synthesized peptide derived from human protein . at AA range: 720-800
特异性
KDM5A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013],
组织表达
Epithelium,Eye,Testis,
细胞定位
Nucleus, nucleolus . Nucleus . Occupies promoters of genes involved in RNA metabolism and mitochondrial function. .
功能
cofactor:Fe(2+).,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
