BD-PB0806

Mouse Dnmt3L Rabbit Polyclonal Antibody

DNA (cytosine-5)-methyltransferase 3-like, Dnmt3l

常规抗体

WB

Human, Mouse

Q9CWR8

NP_001075164.1;NP_062321.1

This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-421 amino acids from mouse Dnmt3L.

WB~~1:1000

48kDa

Rabbit Ig

mDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.

Expressed in testis, thymus, ovary, and heart (PubMed:11306809).

Nucleus.

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.