产品名称
ACTL7A Rabbit Polyclonal Antibody (N-term)
别名
Actin-like protein 7A, Actin-like-7-alpha, ACTL7A
Human Gene ID
NP_006678.1
Human Swissprot No.
Q9Y615
特异性
This ACTL7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-67 amino acids from the N-terminal region of human ACTL7A.
背景介绍
ACTL7A is a member of a family
of actin-related proteins (ARPs) which share significant amino acid
sequence identity to conventional actins. Both actins and ARPs have
an actin fold, which is an ATP-binding cleft, as a common feature.
The ARPs are involved in diverse cellular processes, including
vesicular transport, spindle orientation, nuclear migration and
chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B,
are intronless, and are located approximately 4 kb apart in a
head-to-head orientation within the familial dysautonomia candidate
region on 9q31. Based on mutational analysis of the ACTL7A gene in
patients with this disorder, it was concluded that it is unlikely
to be involved in the pathogenesis of dysautonomia. The ACTL7A gene
is expressed in a wide variety of adult tissues, however, its exact
function is not known.
组织表达
Strongly expressed in testis. Also expressed in other tissues.
细胞定位
Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QY84}. Golgi apparatus {ECO:0000250|UniProtKB:Q9QY84}. Cytoplasm {ECO:0000250|UniProtKB:Q9QY84}. Nucleus {ECO:0000250|UniProtKB:Q9QY84} Note=Detected at the Golgi apparatus during acrosome biogenesis Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail. {ECO:0000250|UniProtKB:Q9QY84}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
