BD-PB0776

ENSA Rabbit Polyclonal Antibody (Center)

Alpha-endosulfine, ARPP-19e, ENSA

常规抗体

WB

Human, Mouse

NP_004427.1;NP_996925.1;NP_996926.1;NP_996927.1;NP_996928.1;NP_996929.1;NP_996930.1;NP_997051.1

O43768

This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.

WB~~1:1000;FC~~1:10~50

13kDa

Rabbit Ig

ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.

Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas

Cytoplasm.

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.