产品名称
INSI2 Rabbit Polyclonal Antibody
蛋白名称
Insulin-induced gene 2 protein (INSIG-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y5U4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5U4/entry
Mouse Swissprot No.
Q91WG1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91WG1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q80UA9
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
INSI2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008],
组织表达
Brain,Hypothalamus,Pituitary,
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
function:Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.,miscellaneous:Does not require nuclear SREBPs for its expression. When nuclear SREBP activity is low, is the only form of INSIG present in the cell.,similarity:Belongs to the INSIG family.,subunit:Binds to the SCAP-SREBF2 complex only in the presence of sterols.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
