产品名称
STIM1 Rabbit Polyclonal Antibody (C-term)
别名
Stromal interaction molecule 1, STIM1, GOK
Human Gene ID
NP_001264891.1;NP_003147.2
Human Swissprot No.
Q13586
特异性
This STIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-538 amino acids from the C-terminal region of human STIM1.
稀释度
WB~~1:1000;IHC-P~~1:100~500
背景介绍
This gene encodes a type 1 transmembrane protein that
mediates Ca2+ influx after depletion of intracellular Ca2+ stores
by gating of store-operated Ca2+ influx channels (SOCs). It is one
of several genes located in the imprinted gene domain of 11p15.5,
an important tumor-suppressor gene region. Alterations in this
region have been associated with the Beckwith-Wiedemann syndrome,
Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung,
ovarian, and breast cancer. This gene may play a role in
malignancies and disease that involve this region, as well as early
hematopoiesis, by mediating attachment to stromal cells. This gene
is oriented in a head-to-tail configuration with the ribonucleotide
reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6
kb from the 5' end of the RRM1 gene.
组织表达
Ubiquitously expressed in various human primary cells and tumor cell lines.
细胞定位
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159) Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
