产品名称
CYP1A1 (4W9)Mouse Monoclonal Antibody(C-term)
别名
Cytochrome P450 1A1, CYPIA1, Cytochrome P450 form 6, Cytochrome P450-C, Cytochrome P450-P1, CYP1A1
Human Gene ID
NP_000490.1
Human Swissprot No.
P04798
特异性
This CYP1A1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 377-405 amino acids from the C-terminal region of human CYP1A1.
背景介绍
This gene, CYP1A1, encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and its
expression is induced by some polycyclic aromatic hydrocarbons
(PAHs), some of which are found in cigarette smoke. The enzyme's
endogenous substrate is unknown; however, it is able to metabolize
some PAHs to carcinogenic intermediates. The gene has been
associated with lung cancer risk. A related family member, CYP1A2,
is located approximately 25 kb away from CYP1A1 on chromosome 15.
组织表达
Lung, lymphocytes and placenta.
细胞定位
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Microsome membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Cytoplasm {ECO:0000250|UniProtKB:P00185}
纯化
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
