产品名称
LOX (7S1)Mouse Monoclonal Antibody(Center)
别名
Protein-lysine 6-oxidase, Lysyl oxidase, LOX
Human Gene ID
NP_002308.2
Human Swissprot No.
P28300
特异性
This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
背景介绍
The protein encoded by this gene is an extracellular
copper enzyme that initiates the crosslinking of collagens and
elastin. The enzyme catalyzes oxidative deamination of the
epsilon-amino group in certain lysine and hydroxylysine residues of
collagens and lysine residues of elastin. In addition to
crosslinking extracellular matrix proteins, the encoded protein may
have a role in tumor suppression. Defects in this gene are a cause
of autosomal recessive cutis laxa type I (CL type I). Two
transcript variants encoding different isoforms have been found for
this gene.
组织表达
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
细胞定位
Secreted. Secreted, extracellular space
纯化
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
