产品名称
IL28B Rabbit Polyclonal Antibody
基因名称
IL28B IFNL3 IFNL4 IL28C ZCYTO22
蛋白名称
Interleukin-28B (IL-28B) (Cytokine Zcyto22) (Interferon lambda-3) (IFN-lambda-3) (Interferon lambda-4) (IFN-lambda-4) (Interleukin-28C) (IL-28C)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IZI9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZI9/entry
Mouse Swissprot No.
Q8CGK6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGK6
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
IL28B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008],
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.,induction:By viral infections or double stranded RNA.,similarity:Belongs to the IL-28/IL-29 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
