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GAD2(8X9)Mouse Monoclonal Antibody

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产品基本信息

产品货号
BD-PB0714
产品名称
GAD2(8X9)Mouse Monoclonal Antibody
别名
Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD65
类别
常规抗体
推荐应用
WB
反应种属
Human, Rat, Mouse
Human Gene ID
NP_000809.1;NP_001127838.1
Human Swissprot No.
Q05329
特异性
This GAD2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 445-473 amino acids from human GAD2.
稀释度
WB~~ 1:500
预测分子量
65kDa
同种型
IgG1
背景介绍
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
细胞定位
Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters
期货
现货
纯化
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Anti- at 1:500 dilution + human brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

All lanes : Anti-GAD2 Antibody at 1:500 dilution Lane 1: rat brain lysate Lane 2: mouse brain lysate Secondary Goat Anti-mouse IgG, (H+L),Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65411 Da Blocking/Dilution buffer: 5% NFDM/TBST.

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