BD-PB0713

GAD2 (4T16)Mouse Monoclonal Antibody(Ascites)

Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD65

常规抗体

WB

Human, Rat

NP_000809.1;NP_001127838.1

Q05329

This GAD2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from human GAD2.

WB~~1:100~1600

65kDa

IgG1

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

现货

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.