产品名称
SWAP70(17H15)Mouse Monoclonal Antibody(Ascites)
别名
Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640
Human Gene ID
NP_055870.2
Human Swissprot No.
Q9UH65
特异性
Purified His-tagged SWAP70 protein(Fragment) was used to produced this monoclonal antibody.
背景介绍
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
组织表达
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
细胞定位
Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448) In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).
纯化
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
