产品名称
SNX6 (11C7)Mouse Monoclonal Antibody(Ascites)
别名
Sorting nexin-6, TRAF4-associated factor 2, Sorting nexin-6, N-terminally processed, SNX6
Human Gene ID
NP_067072.3;NP_689419.2
Human Swissprot No.
Q9UNH7
特异性
This SNX6 monoclonal antibody is generated from mouse immunized with SNX6 recombinant protein.
背景介绍
This gene encodes a member of the sorting nexin family.
Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular
trafficking. This protein associates with the long isoform of the
leptin receptor, the transforming growth factor-beta family of
receptor serine-threonine kinases, and with receptor tyrosine
kinases for platelet-derived growth factor, insulin, and epidermal
growth factor. This protein may form oligomeric complexes with
family member proteins through interactions of both the PX domain
and the coiled coil regions of the molecules. Translocation of this
protein from the cytoplasm to the nucleus occurs after binding to
proviral integration site 1 protein. This gene results in two
transcripts encoding two distinct isoforms.
细胞定位
Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus.
纯化
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
